Hi ,
Thanks for reaching out to Microsoft Q&A.
Yes. If you replace a drive, MARS sees it as a completely different volume because it tracks backup items by volume GUID, not drive letter. That is why your E: paths refused to validate even though the letter was the same. The MARS catalog still pointed to the old GUID, so backups for that volume could never succeed.
There is no supported way to make MARS rebind a backup set to a new volume GUID. Clearing registry keys or restarting services will not fix it. The “resync” references floating around online apply only to consistency checks on existing volumes, not volume identity changes.
The only supported fix is exactly what you ended up doing:
Stop using the vault for that machine.
Delete stored backups.
Reconfigure the MARS backup from scratch, letting it detect the new volume GUID.
If you want to avoid this in the future, the only real option is to avoid drive-level replacement scenarios where the GUID changes. MARS does not support “reattaching” a backup definition to a new disk. Drive letter continuity does not matter; GUID continuity does. Unfortunately, there is no hidden “resync volume mapping” feature today.
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