Hi @O V, Naveen ,
Thanks for your details!
I tested the same method as you and took a look at other posts with the same issue, what I found strange is that all the other shortcuts can be disabled but when it comes "task_manager", it does not work at all.
However, I managed to find a workaround for this. You could try to download the Microsoft PowerToys tool and use its Keyboard Manager feature.
Once you are done installing, Go to the search bar and type "Keyboard Manager":
Go to Remap a shortcut and this should appear:
In here, you can map the Shift + Esc however you want. For my case, I make the shortcut add a text that says "Test" instead and remember to restart Edge again for it to work.
Currently, this is a workaround I find work best, so I hope this helps!
Please let me know how it goes!