Which folders on E:\ and which file on C:\ do you want backed up?
OneDrive can copy folders to the cloud while keeping them on your PC.
Open OneDrive settings, go to Backup, and choose “Manage backup.” Pick the folders you want from E:. For the single C:\ file, put it in a folder OneDrive backs up, or create a new folder in OneDrive and move the file there.
Make sure in Settings > Account > Choose folders that everything you want is selected. This way, OneDrive saves your files online but leaves them on your computer.